A Tensor-Based Morphometry Study of Genetic Influences on Brain Structure Using a New Fluid Registration Method
Identifieur interne : 008636 ( Main/Exploration ); précédent : 008635; suivant : 008637A Tensor-Based Morphometry Study of Genetic Influences on Brain Structure Using a New Fluid Registration Method
Auteurs : Caroline Brun [États-Unis] ; Natasha Leporé [États-Unis] ; Xavier Pennec [France] ; Yi-Yu Chou [États-Unis] ; Agatha D. Lee [États-Unis] ; Marina Barysheva [États-Unis] ; Grieg De Zubicaray [Australie] ; Matthew Meredith [Australie] ; Katie Mcmahon [Australie] ; Margaret J. Wright [Australie] ; Arthur W. Toga [États-Unis] ; Paul M. Thompson [États-Unis]Source :
- Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention ; 2008.
Abstract
We incorporated a new Riemannian fluid registration algorithm into a general MRI analysis method called tensor-based morphometry to map the heritability of brain morphology in MR images from 23 monozygotic and 23 dizygotic twin pairs. All 92 3D scans were fluidly registered to a common template. Voxelwise Jacobian determinants were computed from the deformation fields to assess local volumetric differences across subjects. Heritability maps were computed from the intraclass correlations and their significance was assessed using voxelwise permutation tests. Lobar volume heritability was also studied using the ACE genetic model. The performance of this Riemannian algorithm was compared to a more standard fluid registration algorithm: 3D maps from both registration techniques displayed similar heritability patterns throughout the brain. Power improvements were quantified by comparing the cumulative distribution functions of the
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PubMed: 18982692
PubMed Central: 3086551
Affiliations:
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Lee</name><affiliation wicri:level="2"><nlm:aff id="A1"> Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Barysheva, Marina" sort="Barysheva, Marina" uniqKey="Barysheva M" first="Marina" last="Barysheva">Marina Barysheva</name><affiliation wicri:level="2"><nlm:aff id="A1"> Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="De Zubicaray, Grieg" sort="De Zubicaray, Grieg" uniqKey="De Zubicaray G" first="Grieg" last="De Zubicaray">Grieg De Zubicaray</name><affiliation wicri:level="1"><nlm:aff id="A3"> Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Centre for Magnetic Resonance, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Meredith, Matthew" sort="Meredith, Matthew" uniqKey="Meredith M" first="Matthew" last="Meredith">Matthew Meredith</name><affiliation wicri:level="1"><nlm:aff id="A3"> Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Centre for Magnetic Resonance, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Mcmahon, Katie" sort="Mcmahon, Katie" uniqKey="Mcmahon K" first="Katie" last="Mcmahon">Katie Mcmahon</name><affiliation wicri:level="1"><nlm:aff id="A3"> Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Centre for Magnetic Resonance, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name><affiliation wicri:level="1"><nlm:aff id="A4"> Genetic Epidemiology Lab, QIMR, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Genetic Epidemiology Lab, QIMR, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name><affiliation wicri:level="2"><nlm:aff id="A1"> Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><affiliation wicri:level="2"><nlm:aff id="A1"> Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention</title><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We incorporated a new Riemannian fluid registration algorithm into a general MRI analysis method called tensor-based morphometry to map the heritability of brain morphology in MR images from 23 monozygotic and 23 dizygotic twin pairs. All 92 3D scans were fluidly registered to a common template. Voxelwise Jacobian determinants were computed from the deformation fields to assess local volumetric differences across subjects. Heritability maps were computed from the intraclass correlations and their significance was assessed using voxelwise permutation tests. Lobar volume heritability was also studied using the ACE genetic model. The performance of this Riemannian algorithm was compared to a more standard fluid registration algorithm: 3D maps from both registration techniques displayed similar heritability patterns throughout the brain. Power improvements were quantified by comparing the cumulative distribution functions of the <italic>p</italic>-values generated from both competing methods. The Riemannian algorithm outperformed the standard fluid registration.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Californie</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Sophia-Antipolis</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Brun, Caroline" sort="Brun, Caroline" uniqKey="Brun C" first="Caroline" last="Brun">Caroline Brun</name></region><name sortKey="Barysheva, Marina" sort="Barysheva, Marina" uniqKey="Barysheva M" first="Marina" last="Barysheva">Marina Barysheva</name><name sortKey="Chou, Yi Yu" sort="Chou, Yi Yu" uniqKey="Chou Y" first="Yi-Yu" last="Chou">Yi-Yu Chou</name><name sortKey="Lee, Agatha D" sort="Lee, Agatha D" uniqKey="Lee A" first="Agatha D." last="Lee">Agatha D. Lee</name><name sortKey="Lepore, Natasha" sort="Lepore, Natasha" uniqKey="Lepore N" first="Natasha" last="Leporé">Natasha Leporé</name><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Pennec, Xavier" sort="Pennec, Xavier" uniqKey="Pennec X" first="Xavier" last="Pennec">Xavier Pennec</name></region></country><country name="Australie"><noRegion><name sortKey="De Zubicaray, Grieg" sort="De Zubicaray, Grieg" uniqKey="De Zubicaray G" first="Grieg" last="De Zubicaray">Grieg De Zubicaray</name></noRegion><name sortKey="Mcmahon, Katie" sort="Mcmahon, Katie" uniqKey="Mcmahon K" first="Katie" last="Mcmahon">Katie Mcmahon</name><name sortKey="Meredith, Matthew" sort="Meredith, Matthew" uniqKey="Meredith M" first="Matthew" last="Meredith">Matthew Meredith</name><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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